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GRANTEE SPOTLIGHT

2010 Functional Imaging of Triple Negative Breast Cancet and Identification of Biomarkers to Predict Response to Combined Targeted Therapy

Functional Imaging of Triple-Negative Breast Cancer and Identification of Biomarkers to Predict Response to Combined Targeted Therapy Jennifer M. Specht, M.D., Principal Investigator University of Washington Medicine Seattle, Washington 

 

Triple-negative breast cancer (TNBC) is an aggressive cancer, which often recurs and may be resistant to chemotherapy. Survival for these patients is poorer than for other types of breast cancer. Patients with metastatic or Stage IV TNBC will be treated with a drug that targets blood vessel growth, and tumors will be evaluated before therapy, after two weeks of therapy, and after six months of therapy using PET and MRI scans. In this study, Dr. Specht will look at certain proteins (biomarkers) to determine whether this therapy works better than other traditional chemotherapies in patients with certain characteristics.

2010 Donor Natural Killer Cell Infusions as Prophylactic Adoptive Immunotherapy after MHC-Haploidentical Hematopoietic Cell Transportation

Donor Natural Killer Cell Infusions as Prophylactic Adoptive Immunotherapy after MHC-Haploidentical Hematopoietic Cell Transplantation Brenda M. Sandmaier, M.D., Principal Investigator Fred Hutchinson Cancer Research Center Seattle, Washington

Treatment for many patients with high-risk blood cancers depends on related or unrelated donor transplantation. Survival rate can be as high as 90% for patients with suitably-matched donors. Often, however, family members are not suitable matches and that can lead to rejection of the transplant and low overall survival rates (36% at two years in recent studies). Dr. Sandmeier proposes a regimen of early post-transplant infusion of donor natural killer (NK) cells to current anti-rejection treatment. The NK cells are less toxic than other treatments and can promote strengthening of the immune system.

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